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Page 1
SRD5A polymorphisms and biochemical failure after radical prostatectomy.
Audet-Walsh E, Bellemare J, Nadeau G, Lacombe L, Fradet Y, Fradet V, Huang SP, Bao BY, Douville P, Girard H, Guillemette C, Lévesque E. Audet-Walsh E, et al. Eur Urol. 2011 Dec;60(6):1226-34. doi: 10.1016/j.eururo.2011.06.020. Epub 2011 Jun 29. Eur Urol. 2011. PMID: 21715084
OBJECTIVE: To determine the link between germ-line variations in the steroid-5alpha-reductase, alpha-polypeptide 1 (SRD5A1) and steroid-5alpha-reductase, alpha-polypeptide 2 (SRD5A2) genes and BCR. ...CONCLUSIONS: Our study is the first to show positive associations of sev …
OBJECTIVE: To determine the link between germ-line variations in the steroid-5alpha-reductase, alpha-polypeptide 1 (SRD5A1) and stero …
Antiandrogenic mechanisms of pesticides in human LNCaP prostate and H295R adrenocortical carcinoma cells.
Robitaille CN, Rivest P, Sanderson JT. Robitaille CN, et al. Toxicol Sci. 2015 Jan;143(1):126-35. doi: 10.1093/toxsci/kfu212. Epub 2014 Oct 15. Toxicol Sci. 2015. PMID: 25324206
In the case of prochloraz, some of these effects corresponded with cytotoxicity. H295R cells expressed AR protein and SRD5A1, but not SRD5A2 transcripts. SRD5A1 gene expression in H295R cells was increased by 10 nM DHT, whereas in LNCaP cells significant induction w …
In the case of prochloraz, some of these effects corresponded with cytotoxicity. H295R cells expressed AR protein and SRD5A1, but not …
A common germline variant in CYP11B1 is associated with adverse clinical outcome of treatment with abiraterone or enzalutamide.
Buck SAJ, Meertens M, van Ooijen FMF, Oomen-de Hoop E, de Jonge E, Coenen MJH, Bergman AM, Koolen SLW, de Wit R, Huitema ADR, van Schaik RHN, Mathijssen RHJ. Buck SAJ, et al. Biomed Pharmacother. 2023 Dec 31;169:115890. doi: 10.1016/j.biopha.2023.115890. Epub 2023 Nov 21. Biomed Pharmacother. 2023. PMID: 37988848 Free article.
From the investigated genes CYP17A1, HSD3B1, CYP11B1, AKR1C3, SRD5A1 and SRD5A2, only rs4736349 in CYP11B1 in homozygous form (TT), present in 54 patients (20%), was related with a significantly worse OS (HR = 1.71, 95% CI 1.09 - 2.68, p = 0.019) and TTP (HR = 1.50, 95% CI …
From the investigated genes CYP17A1, HSD3B1, CYP11B1, AKR1C3, SRD5A1 and SRD5A2, only rs4736349 in CYP11B1 in homozygous form (TT), p …
Importance of 5α-reductase gene polymorphisms on circulating and intraprostatic androgens in prostate cancer.
Lévesque É, Laverdière I, Lacombe L, Caron P, Rouleau M, Turcotte V, Têtu B, Fradet Y, Guillemette C. Lévesque É, et al. Clin Cancer Res. 2014 Feb 1;20(3):576-84. doi: 10.1158/1078-0432.CCR-13-1100. Epub 2013 Nov 25. Clin Cancer Res. 2014. PMID: 24277450
PURPOSE: Polymorphisms in the genes SRD5A1 and SRD5A2 encoding androgen biosynthetic 5alpha-reductase enzymes have been associated with an altered risk of biochemical recurrence after radical prostatectomy in localized prostate cancer. ...The SRD5A2 rs676033 variant furthe …
PURPOSE: Polymorphisms in the genes SRD5A1 and SRD5A2 encoding androgen biosynthetic 5alpha-reductase enzymes have been associated wi …
Genetic variations in genes involved in testosterone metabolism are associated with prostate cancer progression: A Spanish multicenter study.
Henríquez-Hernández LA, Valenciano A, Foro-Arnalot P, Álvarez-Cubero MJ, Cozar JM, Suárez-Novo JF, Castells-Esteve M, Fernández-Gonzalo P, De-Paula-Carranza B, Ferrer M, Guedea F, Sancho-Pardo G, Craven-Bartle J, Ortiz-Gordillo MJ, Cabrera-Roldán P, Rodríguez-Melcón JI, Herrera-Ramos E, Rodríguez-Gallego C, Lara PC. Henríquez-Hernández LA, et al. Urol Oncol. 2015 Jul;33(7):331.e1-7. doi: 10.1016/j.urolonc.2015.04.003. Epub 2015 May 7. Urol Oncol. 2015. PMID: 25960412
PURPOSE: To investigate the role of germline variations in cytochrome P450 17A1 (CYP17A1) and steroid-5alpha-reductase, alpha-polypeptides 1 and 2 (SRD5A1 and SRD5A2) genes in PCa. PATIENTS AND METHODS: In total, 494 consecutive Spanish patients diagnosed with nonmetastati …
PURPOSE: To investigate the role of germline variations in cytochrome P450 17A1 (CYP17A1) and steroid-5alpha-reductase, alpha-polypeptides 1 …
Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer.
Setlur SR, Chen CX, Hossain RR, Ha JS, Van Doren VE, Stenzel B, Steiner E, Oldridge D, Kitabayashi N, Banerjee S, Chen JY, Schäfer G, Horninger W, Lee C, Rubin MA, Klocker H, Demichelis F. Setlur SR, et al. Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):229-39. doi: 10.1158/1055-9965.EPI-09-1018. Cancer Epidemiol Biomarkers Prev. 2010. PMID: 20056642
We also investigated associations between SNPs in genes (HSD3B1, SRD5A1/2, and AKR1C2) involved in the conversion of testosterone to DHT, and in DHT metabolism and PCA risk. ...CONCLUSIONS: This is the first study to implicate the 5alpha-reductase isoform 1 (SRD5A1) …
We also investigated associations between SNPs in genes (HSD3B1, SRD5A1/2, and AKR1C2) involved in the conversion of testosterone to …
Role of dutasteride in pre-clinical ETS fusion-positive prostate cancer models.
Ateeq B, Vellaichamy A, Tomlins SA, Wang R, Cao Q, Lonigro RJ, Pienta KJ, Varambally S. Ateeq B, et al. Prostate. 2012 Oct 1;72(14):1542-9. doi: 10.1002/pros.22509. Epub 2012 Mar 13. Prostate. 2012. PMID: 22415461 Free article.
Finally, we tested dutasteride alone or in combination with an anti-androgen in VCaP cell xenografts tumor model. RESULTS: Our data showed that 5alpha-reductase SRD5A1 and SRD5A3 isoenzymes that are responsible for the conversion of testosterone to DHT, are highly expresse …
Finally, we tested dutasteride alone or in combination with an anti-androgen in VCaP cell xenografts tumor model. RESULTS: Our data showed t …
Dietary tomato and lycopene impact androgen signaling- and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis.
Wan L, Tan HL, Thomas-Ahner JM, Pearl DK, Erdman JW Jr, Moran NE, Clinton SK. Wan L, et al. Cancer Prev Res (Phila). 2014 Dec;7(12):1228-39. doi: 10.1158/1940-6207.CAPR-14-0182. Epub 2014 Oct 14. Cancer Prev Res (Phila). 2014. PMID: 25315431 Free PMC article.
Expression of genes involved in androgen metabolism/signaling pathways is reduced by lycopene feeding (Srd5a1) and by tomato feeding (Srd5a2, Pxn, and Srebf1). In addition, tomato feeding significantly reduced expression of genes associated with stem cell features, Aldh1a …
Expression of genes involved in androgen metabolism/signaling pathways is reduced by lycopene feeding (Srd5a1) and by tomato feeding …
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.
Lunardi A, Ala U, Epping MT, Salmena L, Clohessy JG, Webster KA, Wang G, Mazzucchelli R, Bianconi M, Stack EC, Lis R, Patnaik A, Cantley LC, Bubley G, Cordon-Cardo C, Gerald WL, Montironi R, Signoretti S, Loda M, Nardella C, Pandolfi PP. Lunardi A, et al. Nat Genet. 2013 Jul;45(7):747-55. doi: 10.1038/ng.2650. Epub 2013 Jun 2. Nat Genet. 2013. PMID: 23727860 Free PMC article.
Mechanistically, the integrated acquisition of data from mouse models and patients identifies the expression patterns of XAF1, XIAP and SRD5A1 as a predictive and actionable signature for CRPC. Notably, we show that combined inhibition of XIAP, SRD5A1 and AR pathway …
Mechanistically, the integrated acquisition of data from mouse models and patients identifies the expression patterns of XAF1, XIAP and S …
24 results